Researcher biography

I completed my B.Sc. with majors in Biochemistry and Organic Chemistry and subsequently my M.Sc. in Clinical Biochemistry at the University of Western Australia, before later completing my Ph.D. in the Faculty of Medicine at The University of Sydney.  I have worked in the areas of pharmacology particularly in relation to drugs acting on the central nervous system, behavioural pharmacology, bioanalysis and assay validation, pharmacokinetics, pharmacodynamics, drug metabolism, and drug development.  I have worked extensively with LC-MS, HPLC, and GC-MS, and also with laboratory rodent models.  Earlier work while working as a Research Academic for Prof Laurie Mather in the Department of Anaesthesia and Pain Management at the University of Sydney included studies of the pharmacokinetics, pharmacodynamics, and biodistribution of thiopentone enantiomers, in addition to studies of the pharmacokinetics and biodistribution of ketamine enantiomers.  I have been working as a Research Officer for Professor Maree Smith since 2002, initially in The School of Pharmacy and then in the Center for Integrated Preclinical Drug Development/TetraQ at The University of Queensland, and have worked on a number of projects which have included the pharmacokinetics of morphine and oxycodone and their respective primary metabolites, and the development of LC-MS assays for angiotensin II type 2 receptor antagonists.  More recently, I have worked on the evaluation and validation of 2 transgenic mouse models of Alzheimer’s disease using the Morris water maze, as part of a collaborative research grant held by Prof Maree Smith.  Currently, I have been engaged working with WinNonlin software for the pharmacokinetic analysis of clinical trial data, and with scientific writing for commercial research projects.   To date I have 32 publications in international peer reviewed journals.
 
Selected publications
 
Smith MT, Wyse BD, Edwards SR, El-Tamimy T, Gaetano G, Gavin P.  Topical application of a novel oxycodone gel formulation (tocopheryl phosphate mixture) in a rat model of peripheral inflammatory pain produces localized pain relief without significant systemic exposure.  J Pharm Sci 2015; 104: 2388-2396
 
Edwards SR, Hamlin AS, Marks N, Coulson EJ, Smith MT.  Comparative studies using the Morris water maze to assess spatial memory deficits in two transgenic mouse models of Alzheimer’s disease.  Clin Exp Pharmacol Physiol 2014; 41:798-806
 

Smith MT, Wyse BD, Edwards SR.  Small molecule angiotensin II type 2 receptor (AT2R) antagonists as novel analgesics for neuropathic pain: comparative pharmacokinetics, radioligand binding and efficacy in rats.  Pain Medicine 2013; 14:692-705